Spravato (esketamine) 84 mg is a prescription nasal spray used alongside an oral antidepressant to treat treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. Because each individual, single-use nasal spray device delivers a fixed dose of 28 mg, an 84 mg treatment session requires the consecutive use of three separate nasal spray devices Due to the risk of serious side effects, Spravato cannot be taken at home. It must be administered under direct healthcare supervision within a certified medical facility If your doctor has prescribed the 84 mg dose kit, your in-clinic session will typically follow these standardized administration steps