Quagen promethazine with codeine is a prescription oral solution manufactured by Quagen Pharmaceuticals. It is a combination medication containing 6.25 mg of promethazine hydrochloride (an antihistamine) and 10 mg of codeine phosphate (an opioid cough suppressant) per 5 mL dose Because it contains an opioid, it is classified as a Schedule V federal controlled substance due to its potential for abuse, misuse, addiction, and physical dependence. Approved Use: It is FDA-approved only for the temporary relief of coughs and upper respiratory symptoms caused by allergies or the common cold Adults Only: It is strictly indicated for adults 18 years of age and older. Standard Adult Dosage: The typical dose is 5 mL orally every 4 to 6 hours as needed. You must never exceed 6 doses (30 mL) in any 24-hour window. Always measure the liquid with an accurate milliliter syringe or dosing cup, never a standard kitchen spoon • Pediatric Danger: It is strictly contraindicated in children under 12 years old, and should not be given to anyone under 18. Children face an elevated, life-threatening risk of severe breathing problems (respiratory depression) and fatal overdose.
• Respiratory Depression: Codeine can slow down your breathing to dangerous or fatal levels, especially when first starting the drug or increasing a dose.
• Central Nervous System (CNS) Depressants: Combining this syrup with alcohol, benzodiazepines, or other sedatives can cause extreme drowsiness, coma, or death.
• Contraindications: Do not take this medication if you have severe asthma, significant lung/breathing problems, a gastrointestinal blockage, or if you have taken a Monoamine Oxidase Inhibitor (MAOI) antidepressant within the last 14 days